In this study, we examined goal-focused hope as a potential mediator between the association of multidimensional spirituality and depressive symptoms in a sample of 319 college students. Results of conducting a series of multiple mediation tests indicated that hope agency, but not hope pathways, fully and significantly accounted for the associations of ritualistic, theistic, and existential spirituality with depressive symptoms. Overall, our findings offer support for the contention that hope agency plays an important role in accounting for the association between spirituality and psychological adjustment in college students. Some implications of the present findings are discussed.